Graduate Courses

Note: Students may also take courses from other engineering departments within Duke's Pratt School of Engineering, and courses from other graduate schools at Duke with the permission of the adviser and the Director of Graduate Studies.

Approved Life Science Electives

  • BIO 201L(101L) Gateway to Biology: Molecular Biology
  • BIO 202L(102L) Gateway to Biology: Genetics and Evolution
  • BIO 220(119) Cell and Developmental Biology
  • BIO 224(154) Fundamentals in Neuroscience
  • BIOCHEM 622(222) Structure of Biological Macromolecules
  • BIOCHEM 301(227) Introductory Biochemistry I: Intermediary Metabolism
  • BIOCHEM 302(228) Introductory Biochemistry II
  • BIOCHEM 681(291) Physical Biochemistry
  • CBB 520(220) Genome Tools and Technologies
  • CBB 540(240) Statistical Methods for Computational Biology
  • CBB 541(241) Statistical Genetics
  • CELLBIO 503(203) Introduction to Physiology
  • CELLBIO 551(251) Cell and Molecular Physiology
  • CELLBIO 760(417) Cellular Signaling
  • CMB 747(247) Macromolecular Synthesis
  • CMB 797(297) Modern Techniques in Molecular Biology
  • EVANTH 730(305) Gross Human Anatomy
  • IMM 544(244) Principles of Immunology
  • IMM 800(291) Comprehensive Immunology
  • IMM 900(300) Tumor Immunology
  • MEDPHY 505(205) Anatomy and Physiology for Medical Physicists
  • MGM 532(232) Human Genetics
  • MGM 700(300) Gene Regulation
  • NBI 719(319) Concepts in Neuroscience
  • NBI 751(351) Molecular Neurobiology

Approved Advanced Math Courses

  • CBB 540(240) Statistical Methods for Computational Biology
  • CE 501(202) Applied Mathematics for Engineers
  • CE 530(254) Introduction to the Finite Element Method
  • CE 630(255) Nonlinear Finite Element Analysis
  • COMPSCI 520(250) Numerical Analysis
  • MATH 545(219) Introduction to Stochastic Calculus
  • MATH 551(211) Applied Partial Differential Equations & Complex Variables
  • MATH 561(224) Scientific Computing I
  • MATH 575(228) Mathematical Fluid Dynamics
  • MATH 577(229) Mathematical Modeling
  • ME 577(229) Computational Fluid Mechanics and Heat Transfer
  • PHYSICS 760(301) Mathematical Methods in Physics
  • STATS 601(290L) Modern Statistical Data Analysis

Biomedical Engineering Course Descriptions

301L(201L). Electrophysiology (AC or GE). The electrophysiology of excitable cells from a quantitative perspective. Topics include the ionic basis of action potentials, the Hodgkin-Huxley model, impulse propagation, source-field relationships, and an introduction to functional electrical stimulation. Students choose a relevant topic area for detailed study and report. Not open to students who have taken Biomedical Engineering 101L or equivalent. Instructor: Barr, Bursac, Grill, Henriquez, or Neu. 4 units. C-L: Neuroscience 301L(201L)

302L(202L). Fundamentals of Biomaterials and Biomechanics (AC or GE). This course will cover principles of physiology, materials science and mechanics with particular attention to topics most relevant to biomedical engineering. Areas of focus include the structure-functional relationships of biocomposites including biological tissues and biopolymers; extensive treatment of the properties unique to biomaterials surfaces; behavior of materials in the physiological environment, and biomechanical failure criterion. The course includes selected experimental measurements in biomechanical and biomaterial systems. Prerequisites: Math 353(108); Engineering 201L(75L); Mechanical Engineering 221L(83L). Instructor: Staff. 3 units.

303(233). Modern Diagnostic Imaging Systems (AC or GE). The underlying concepts and instrumentation of several modern medical imaging modalities. Review of applicable linear systems theory and relevant principles of physics. Modalities studied include X-ray radiography (conventional film-screen imaging and modern electronic imaging), computerized tomography (including the theory of reconstruction), and nuclear magnetic resonance imaging. Prerequisite: Biomedical Engineering 271(171), junior or senior standing. Consent of instructor required. Instructor: Smith or Trahey. 3 units.

307(207). Transport Phenomena in Biological Systems (AC or GE, BB). An introduction to the modeling of complex biological systems using principles of transport phenomena and biochemical kinetics. Topics include the conservation of mass and momentum using differential and integral balances; rheology of Newtonian and non-Newtonian fluids; steady and transient diffusion in reacting systems; dimensional analysis; homogeneous versus heterogeneous reaction systems. Biomedical and biotechnological applications are discussed. Prerequisites: Biomedical Engineering 260L(100L) and Mathematics 353(108); or consent of the instructor. Instructor: Friedman, Katz, Truskey, or Yuan. 3 units. C-L: Civil Engineering 307(207), Mechanical Engineering and Materials Science 307(207).

427L(227L). Design in Biotechnology (DR or GE, MC, BB). Design of custom strategies to address real-life issues in the development of biocompatible and biomimetic devices for biotechnology or biomedical applications. Student teams will work with a client in the development of projects that incorporate materials science, biological transport and biomechanics. Formal engineering design principles will be emphasized; overview of intellectual properties, engineering ethics, risk analysis, safety in design and FDA regulations will be reviewed. Oral and written reports, and prototype development will be required. This course is intended as a capstone design course for the upper-level undergraduate biomedical engineering students with a focused interest in bimolecular science, biotechnology, transport, drug delivery, biomechanics and related disciplines. Prerequisites: BME 307(207), Statistics 130(113), or equivalent. Instructors: Gimm. 3 units.

436L(236L). Biophotonic Instrumentation (DR or GE, IM). Theory and laboratory practice in optics, and in the design of optical instruments for biomedical applications. Section I focuses on basic optics theory and laboratory practice. Section II focuses on deeper understanding of selected biophotonic instruments, including laboratory work. Section III comprises the design component of the course. In this part, student teams are presented with a design challenge, and work through the steps of engineering design culminating in building a prototype solution to the design challenge. Lecture topics include engineering design, intellectual property protection, engineering ethics, and safety. Prerequisites: Biomedical Engineering 354L(154L) and Statistics 130(113). Instructor: Izatt or Wax. 3 units.

60L(260L). Devices for People with Disabilities (DR or GE, IM, BB). Design of custom devices to aid disabled individuals. Students will be paired with health care professionals at local hospitals who will supervise the development of projects for specific clients. Formal engineering design principles will be emphasized; overview of assistive technologies, patent issues, engineering ethics. Oral and written reports will be required. Selected projects may be continued as independent study. Prerequisite: Biomedical Engineering 354L(154L) and Statistics 130(113). Instructor: Bohs or Goldberg. 3 units.

461L(261L). Electronic Designs for the Developing World (DR or GE, IM). Design of custom devices to help the specific and unique needs of developing world hospitals. Formal engineering design principles will be emphasized; overview of developing world conditions, patent issues, engineering ethics. Designs must be based on microcontroller or equivalent electronic circuitry. Oral and written reports will be required. Students may elect to personally deliver their projects to a developing world hospital, if selected, in the summer following the course. Prerequisites: Biomedical Engineering 354L(154L) and Statistics 130(113). Consent of instructor required. Instructor: Malkin. 3 units.

462L(262L). Design for the Developing World (DR or GR). Design of custom devices to help the specific and unique needs of developing world hospitals. Formal engineering design principles will be emphasized; overview of developing world conditions, patent issues, engineering ethics. Oral and written reports will be required. Students may elect to personally deliver their projects to a developing world hospital, if selected, in the summer following the course. Prerequisite: Biomedical Engineering 354L(154L) and Statistics 130(113). Instructor: Malkin. 3 units.

464L(264L). Medical Instrument Design (DR or GE, IM). General principles of signal acquisition, amplification processing, recording, and display in medical instruments. System design, construction, and evaluation techniques will be emphasized. Methods of real-time signal processing will be reviewed and implemented in the laboratory. Each student will design, construct, and demonstrate a functional medical instrument and collect and analyze data with that instrument. Formal write-ups and presentations of each project will be required. Prerequisite: Biomedical Engineering 354L(154L) and Statistics 130(113), or equivalent or senior standing. Instructor: Malkin, S. Smith, Trahey, or Wolf. 4 units.

502(252). Neural Signal Acquisition (GE, IM, EL). This course will be an exploration of analog and digital signal processing techniques for measuring and characterizing neural signals. the analog portion will cover electrodes, amplifiers, filters and A/D converters for recording neural electrograms and EEGs. The digital portion will cover methods of EEG processing including spike detection and spike sorting. A course pack of relevant literature will be used in lieu of a textbook. Students will be required to write signal-processing algorithms. Prerequisite: Biomedical Engineering 354L(154L). Instructor: Wolf. 3 units. C-L: Neuroscience 502(252)

503(253). Computational Neuroengineering (GE, EL). This course introduces students to the fundamentals of computational modeling of neurons and neuronal circuits and the decoding of information from populations of spike trains. Topics include: integrate and fire neurons, Spike Response Models, Homogeneous and Inhomogeneous Poisson processes, neural circuits, Weiner (optimal), Adaptive Filters, neural networks for classification, population vector coding and decoding. Programming assignments and projects will be carried out using MATLAB. Prerequisites: BME 101/201 or equivalent. Instructor: Henriquez. 3 units. C-L: Neuroscience 503(253).

504(254). Fundamentals of Electrical Stimulation of the Nervous System (GE, EL). This course presents a quantitative approach to the fundamental principles, mechanisms, and techniques of electrical stimulation required for non-damaging and effective application of electrical stimulation. Consent of instructor required. Instructor: Grill. 3 units.

506(204). Measurement and Control of Cardiac Electrical Events (GE, IM, EL). Design of biomedical devices for cardiac application based on a review of theoretical and experimental results from cardiac electrophysiology. Evaluation of the underlying cardiac events using computer simulations. Examination of electrodes, amplifiers, pacemakers, and related computer apparatus. Construction of selected examples. Prerequisites: Biomedical Engineering 253L(153L) or equivalents. Instructor: Wolf. 3 units.

511(211). Theoretical Electrophysiology (GE, EL). Advanced topics on the electrophysiological behavior of nerve and striated muscle. Source-field models for single-fiber and fiber bundles lying in a volume conductor. Forward and inverse models for EMG and ENG. Bidomain model. Model and simulation for stimulation of single-fiber and fiber bundle. Laboratory exercises based on computer simulation, with emphasis on quantitative behavior and design. Readings from original literature. Prerequisite: Biomedical Engineering 301L(201L) or equivalent. Instructor: Barr or Neu. 4 units. C-L: Neuroscience 511(241)

512L(212L). Theoretical Electrocardiography (GE, EL). Electrophysiological behavior of cardiac muscle. Emphasis on quantitative study of cardiac tissue with respect to propagation and the evaluation of sources. Effect of junctions, inhomogeneities, anisotropy, and presence of unbounded extracellular space. Bidomain models. Study of models of arrhythmia, fibrillation, and defibrillation. Electrocardiographic models and forward simulations. Laboratory exercises based on computer simulation, with emphasis on quantitative behavior and design. Readings from original literature. Prerequisite: Biomedical Engineering 301L(201L) or equivalent. Instructor: Barr. 4 units.

513(213). Nonlinear Dynamics in Electrophysiology (GE, EL). Electrophysiological behavior of excitable membranes and nerve fibers examined with methods of nonlinear dynamics. Phase-plane analysis of excitable membranes. Limit cycles and the oscillatory behavior of membranes. Phase resetting by external stimuli. Critical point theory and its applications to the induction of rotors in the heart. Theory of control of chaotic systems and stabilizing irregular cardiac rhythms. Initiation of propagation of waves and theory of traveling waves in a nerve fiber. Laboratory exercises based on computer simulations, with emphasis on quantitative behavior and design. Readings from original literature. Prerequisite: Mathematics 216(107) or equivalent. Instructor: Neu. 4 units.

515(256). Neural Prosthetic Systems. This course will cover several systems that use electrical stimulation or recording of the nervous system to restore function following disease or injury. For each system the course will cover the underlying biophysical basis for the treatment,the technology underlying the treatment,and the associated clinical applications and challenges. Systems to be covered include cochlear implants, spinal cord stimulation of pain, vagus nerve stim. for epilepsy, deep brain stim. for movement disorders, sacral root stim. for bladder dysfunction, and neuromuscular electrical stim.for restoration of movement. Prerequisites: Biomedical Engineering 253L(153L), and consent of instructor. Instructor: Grill. 3 units.

516(246). Computational Methods in Biomedical Engineering (GE). Introduction to practical computational methods for data analysis and simulation with a major emphasis on implementation. Methods include numerical integration and differentiation, extrapolation, interpolation, splining FFTs, convolution, ODEs, and simple one- and two-dimensional PDEs using finite differencing. Introduction to concepts for optimizing codes on a CRAY-YMP. Examples from biomechanics, electrophysiology, and imaging. Project work included and students must have good working knowledge of Unix, Fortran, or C. Intended for graduate students and seniors who plan on attending graduate school. Prerequisite: Engineering 110L(53L) or equivalent, Mathematics 216(107) or equivalent, or consent of instructor. Instructor: Henriquez. 3 units.

522L(242L). Introduction to Bionanotechnology Engineering. A general overview of nanoscale science/physical concepts will be presented as those concepts tie in with current nanoscience and nanomedicine research. Students will be introduced to the principle that physical scale impacts innate material properties and modulates how a material interacts with its environment. Important concepts such as surface-to-volume ratio, friction, electronic/optical properties, self-assembly (biological and chemical) will be contextually revisited. A number of laboratory modules ("NanoLabs") will guide students through specific aspects of nanomedicine, nanomaterials, and engineering design. Prerequisites: BME 83L and BME 260L(100L) or consent of instructor. 3 units.

525(215). Biomedical Materials and Artificial Organs (GE, BB). Chemical structures, processing methods, evaluation procedures, and regulations for materials used in biomedical applications. Applications include implant materials, components of ex vivo circuits, and cosmetic prostheses. Primary emphasis on polymer-based materials and on optimization of parameters of materials which determine their utility in applications such as artificial kidney membranes and artificial arteries. Prerequisite: Biomedical Engineering 83L and 260L(100L) or their equivalent or consent of instructor. Instructor: Reichert. 3 units. C-L: Mechanical Engineering and Materials Science 518(215)

526(206L). Elasticity (GE, BB). Linear elasticity will be emphasized including concepts of stress and strain as second order tensors, equilibrium at the boundary and within the body, and compatibility of strains. Generalized solutions to two and three dimensional problems will be derived and applied to classical problems including torsion of noncircular sections, bending of curved beams, stress concentrations and contact problems. Applications of elasticity solutions to contemporary problem in civil and biomedical engineering will be discussed. Prerequisites: Engineering 201L(75L); Mathematics 353(108). Instructor: Laursen. 3 units. C-L: Civil Engineering 521(206).

527(217). Cell Mechanics and Mechanotransduction. This course examines the mechanical properties of cells and forces exerted by cells in biological processes of clinical and technological importance and the processes by which mechanical forces are converted into biochemical signals and activate gene expression. Topics covered include measurement of mechanical properties of cells, cytoskeleton mechanics, models of cell mechanical properties, cell adhesion, effects of physical forces on cell function, and mechanotransduction. Students will critically evaluate current literature and analyze models of cell mechanics and mechanotransduction. Prerequisites: Engineering 201L(75) and Biomedical Engineering 307(207) or equivalent, knowledge of cell biology and instructor consent. Instructror: Truskey. 3 units.

528(275). Introduction to Biofluid Mechanics. Methods and applications of fluid mechanics in biological and biomedical systems including: Governing equations and methods of solutions,(e.g. conservation of mass flow and momentum), the nature of biological fluids, (e.g.non Newtonian rheological behavior),basic problems with broad relevance, (e.g. flow in pipes, lubrication theory), applications to cells and organs in different physiological systems, (e.g. cardiovascular, gastrointestinal, respiratory, reproductive and musculoskeletal systems), applications to diagnosis and therapy, (e.g.drug delivery and devices). Prerequisite: Biomedical Engineeering 307(207). Instructor: Katz. 3 units.

529(208). Theoretical and Applied Polymer Science (GE, BB). 3 units. C-L: see Mechanical Engineering and Materials Science 514(211)

530(230). Tissue Biomechanics (GE, BB). Introduction to the mechanical behaviors of biological solids and fluids with application to tissues, cells and molecules of the musculoskeletal and cardiovascular systems. Topics to be covered include static force analysis and optimization theory, biomechanics of linearly elastic solids and fluids, anisotropic behaviors of bone and fibrous tissues, blood vessel mechanics, cell mechanics and behaviors of single molecules. Emphasis will be placed on modeling stress-strain relations in these tissues, and experimental devices used to measure stress and strain. Student seminars on topics in applied biomechanics will be included. Prerequisites: Engineering 201L(75L); Mathematics 353(108). Instructor: Myers or Setton. 3 units.

531(231). Intermediate Biomechanics (GE, BB). Introduction to solid and orthopaedic biomechanical analyses of complex tissues and structures. Topics to be covered include: spine biomechanics, elastic modeling of bone, linear and quasi-linear viscoelastic properties of soft tissue (for example, tendon and ligament), and active tissue responses (for example, muscle). Emphasis will be placed on experimental techniques used to evaluate these tissues. Student seminars on topics in applied biomechanics will be included. Prerequisites: Engineering 201L(75L); Mathematics 353(108). Instructor: Myers or Setton. 3 units.

542(222). Principles of Ultrasound Imaging (GE, IM). Propagation, reflection, refraction, and diffraction of acoustic waves in biologic media. Topics include geometric optics, physical optics, attenuation, and image quality parameters such as signal-to-noise ratio, dynamic range, and resolution. Emphasis is placed on the design and analysis of medical ultrasound imaging systems. Prerequisites: Mathematics 216(107) and Physics 152L(62L). Instructor: von Ramm. 3 units.

545(235). Acoustics and Hearing (GE, IM). The generation and propagation of acoustic (vibrational) waves and their reception and interpretation by the auditory system. Topics under the heading of generation and propagation include free and forced vibrations of discrete and continuous systems, resonance and damping, and the wave equation and solutions. So that students may understand the reception and interpretation of sound, the anatomy and physiology of the mammalian auditory system are presented; and the mechanics of the middle and inner ears are studied. Prerequisites: Biomedical Engineering 271(171) or equivalent and Mathematics 216(107). Instructor: Collins or Trahey. 3 units. C-L: Electrical and Computer Engineering 584(284).

560(210). Molecular Basis of Membrane Transport (GE, MC, EL). Transport of substances through cell membranes examined on a molecular level, with applications of physiology, drug delivery, artificial organs and tissue engineering. Topics include organization of the cell membrane, membrane permeability and transport, active transport and control of transport processes. Assignments based on computer simulations, with emphasis on quantitative behavior and design. Prerequisites: Mathematics 216(107) or equivalent. Instructors: Friedman or Neu. 3 units. C-L: Neuroscience 560(240)

561L(258L). Genome Science & Technology Lab (GE, MC). Hands-on experience on using and developing advanced technology platforms for genomics and proteomics research. Experiments may include nucleic acid amplification and quantification, lab-on-chip, bimolecular separation and detection, DNA sequencing, SNP genotyping, microarrays, and synthetic biology techniques. Laboratory exercises and designing projects are combined with lectures and literature reviews. Prior knowledge in molecular biology and biochemistry is required. Instructor consent required. Instructor: Tian. Variable credit. C-L: Computational Biology and Bioinformatics 542(222)

565L(240L). Environmental Molecular Biotechnology (GE, MC). 3 units. C-L: see Civil Engineering 661L(239L)

566(216). Transport Phenomena in Cells and Organs (GE, MC). Applications of the principles of mass and momentum transport to the analysis of selected processes of biomedical and biotechnological interest. Emphasis on the development and critical analysis of models of the particular transport process. Topics include: reaction-diffusion processes, transport in natural and artificial membranes, dynamics of blood flow, pharmacokinetics, receptor-mediated processes and macromolecular transport, normal and neoplastic tissue. Prerequisite: Biomedical Engineering 307(207) or equivalent. Instructor: Truskey or Yuan. 3 units.

567(237). Biosensors (GE, IM, MC). Biosensors are defined as the use of biospecific recognition mechanisms in the detection of analyte concentration. The basic principles of protein binding with specific reference to enzyme-substrate, lectin-sugar, antibody-antigen, and receptor-transmitting binding. Simple surface diffusion and absorption physics at surfaces with particular attention paid to surface binding phenomena. Optical, electrochemical, gravimetric, and thermal transduction mechanisms which form the basis of the sensor design. Prerequisites: Biomedical Engineering 260L(100L) or equivalent and consent of instructor. Instructor: Reichert or Vo-Dinh. 3 units.

568(228). Laboratory in Cellular and Biosurface Engineering (GE, MC). Introduction to common experimental and theoretical methodologies in cellular and biosurface engineering. Experiments may include determination of protein and peptide diffusion coefficients in alginate beads, hybridoma cell culture and antibody production, determination of the strength of cell adhesion, characterization of cell adhesion or protein adsorption by total internal reflection fluorescence, and Newtonian and non-Newtonian rheology. Laboratory exercises are supplemented by lectures on experiment design, data analysis, and interpretation. Prerequisites: Biomedical Engineering 307(207) or equivalent. Instructor: Truskey. 3 units.

570L(220L). Introduction to Biomolecular Engineering (GE, BB, MC). Structure of biological macromolecules, recombinant DNA techniques, principles of and techniques to study protein structure-function. Discussion of biomolecular design and engineering from the research literature. Linked laboratory assignments to alter protein structure at the genetic level. Expression, purification, and ligand-binding studies of protein function. Consent of instructor required. Instructor: Chilkoti. 3 units.

574(221). Modeling and Engineering Gene Circuits. This course discusses modeling and engineering gene circuits, such as prokaryotic gene expression, cell signaling dynamics, cell-cell communication, pattern formation, stochastic dynamics in cellular networks and its control by feedback or feedforward regulation, and cellular information processing. The theme is the application of modeling to explore "design principles" of cellular networks, and strategies to engineer such networks. Students need to define an appropriate modeling project. At the end of the course, they're required to write up their results and interpretation in a research-paper style report and give an oral presentation. Prerequisites: Biomedical Engineering 260L(100L) or consent of instructor. Instructor: You. 3 units.

577(247). Drug Delivery (GE, BB, MC). Introduction to drug delivery in solid tumors and normal organs (for example, reproductive organs, kidney, skin, eyes). Emphasis on quantitative analysis of drug transport. Specific topics include: physiologically-based pharmacokinetic analysis, microcirculation, network analysis of oxygen transport, transvascular transport, interstitial transport, transport across cell membrane, specific issues in the delivery of cells and genes, drug delivery systems, and targeted drug delivery. Prerequisite: Biomedical Engineering 307(207) and Engineering 110L(53). Instructor: Yuan. 3 units.

578(248). Tissue Engineering (GE, MC). This course will serve as an overview of selected topics and problems in the emerging field of tissue engineering. General topics include cell sourcing and maintenance of differentiated state, culture scaffolds, cell-biomaterials interactions, bioreactor design, and surgical implantation considerations. Specific tissue types to be reviewed include cartilage, skin equivalents, blood vessels, myocardium and heart valves, and bioartificial livers. Prerequisites: Mathmetics 353(108) or consent of instructor. Instructor: Bursac. 3 units.

590(265). Advanced Topics in Biomedical Engineering. Advanced subjects related to programs within biomedical engineering tailored to fit the requirements of a small group. Consent of instructor required. Instructor: Staff. 3 units.

590L(265L). Advanced Topics with Lab. To be used as a "generic" course number for any advanced topics course with lab sections. Instructor: Staff. 3 units.

702S(311). BME Graduate Seminars. Two semester, weekly seminars series required of all BME graduate students. Students are exposed to the breadth of research topics in BME via seminars given by BME faculty, advanced graduate students, and invited speakers. At the end of each semester students are required to write a synopsis of the seminars attended. More than three unexcused absences will result in a failing grade. Instructor: Staff. 0 units.

711S(301). Biological Engineering Seminar Series (CBIMMS and CBTE). 1 unit. C-L: see Mechanical Engineering and Materials Science 717S(301).

712S(302). Biological Engineering Seminar Series (CBIMMS and CBTE). 1 unit. C-L: see Mechanical Engineering and Materials Science 718S(302).

717S(351). Seminars in Medical Physics. Medical physics is the application of the concepts and methods of physics and engineering to the diagnosis and treatment of human disease. This course consists of weekly lectures covering broad topics in medical physics including diagnostic imaging, radiation oncology, radiation safety, and nuclear medicine. Lectures will be given by invited speakers drawn from many university and medical center departments including Biomedical Engineering, radiology, physics, radiation safety, and radiation oncology. Prerequisites: background in engineering or physics. 1 CC (0.5 ES/0.5 ED). Consent of instructor required. Instructor: Lo and Samei. 1 unit.

785(350). Principles of Research Management. A survey of topics in modern research management techniques that will cover proven successful principles and their application in the areas of research lab organization, resource management, organization of technical projects, team leadership, financial accountability, and professional ethics. Instructor: Staff. 1 unit.

717S(351). Seminars in Medical Physics. Medical physics is the application of the concepts and methods of physics and engineering to the diagnosis and treatment of human disease. This course consists of weekly lectures covering broad topics in medical physics including diagnostic imaging, radiation oncology, radiation safety, and nuclear medicine. Lectures will be given by invited speakers drawn from many university and medical center departments including Biomedical Engineering, radiology, physics, radiation safety, and radiation oncology. Prerequisites: background in engineering or physics. 1 CC (0.5 ES/0.5 ED). Consent of instructor required. Instructor: Lo and Samei. 1 unit.

787(360). Leading Medical Devices: Innovation to Market. Interdisciplinary examination of the medical device landscape for business, engineering, and medicine. Provides core tools for individuals interested in product design and development. Includes market definition and modeling, financing, reimbursement, business plan modeling, and the global marketplace. Case-based and team-based learning including developing a business plan and 510K approval will augment core instruction and guest lecturers. Consent of instructor required. Instructor: Chopra. 3 units.

788(362). Invention to Application: Healthcare Research Commercialization. Interdisciplinary teams of students from engineering, medical science, business, and medicine work together to understand and evaluate the commercial potential of Duke faculty research innovations and develop a comprehensive research translation and business plan for one chosen opportunity. Learning includes understanding technology, product development, marketing, finance, regulatory requirements, and reimbursement. In addition to weekly lectures, students are mentored in this real world experience by a team including technology transfer experts, venture capitalists, researchers, physicians, and entrepreneurs. Prerequisites: none. Consent of instructor required. Instructor: Myers, Uzbil. 3 units.

790(365). Advanced Topics for Graduate Students in Biomedical Engineering. Advanced subjects related to programs within biomedical engineering tailored to fit the requirements of a small group. Consent of instructor required. Instructor: Staff. 3 units.

791. Independent Studies. For graduate students who have shown aptitude for research in one area of biomedical engineering. Consent of instructor required. Instructor: Staff. 3 units.

830(329). Continuum Biomechanics. Introduction to conservation laws and thermodynamic principles of continuum mechanics with application to tissues of the musculoskeletal and cardiovascular systems. Topics cover nonlinear and anisotropic behaviors of solids and fluids. Emphasis on the application of hyperelastic constitutive formulations to determination of stress and strain fields in deformations of calcified tissues (for example, cortical and trabecular bone), soft tissues (for example, ligament, cartilage, cornea, intervertebral disc, left ventricle, aorta), and biological fluids (for example, mucus, synovial fluid, polymer solutions). Tensor fields and indicial notation. Prerequisites: Engineering 110L(75L) or equivalent, and Mathematics 111 or equivalent. Instructor: Setton. 3 units.

832(330). Finite Element Method for Biomedical Engineers. The finite element method with an emphasis on applications to biomedical engineering. Several detailed examples illustrate the finite element analysis process, which includes setting up a mathematical description of the problem, putting it into a form suitable for finite element solution, solving the discretized problem, and using advanced computer codes to check the correctness of the numerical results. Consent of instructor required. Instructor: Staff. 3 units.

834(331). Viscoelasticity. Viscoelasticity of hard and soft tissue solids and composite structures. Linear and nonlinear one-dimensional viscoelastic behavior, internal damping, and three-dimensional viscoelasticity. Approximation techniques for determination of viscoelastic constitutive equations from experimental data. Mathematical formulations for the characterization of the dynamic behavior of biologic structures. Consent of instructor required. Instructor: Myers. 3 units.

836(340). Mechanics of Multiphase Biological Tissues. Introduction to constitutive modeling of multiphase mixtures with application to biological tissues (for example, skin, cornea, ligament, cartilage, intervertebral disc). Fundamental conservation laws and thermodynamic principles of the theory of mixtures will be reviewed. Development of constitutive equations for mixtures containing inviscid and viscous fluids, as well as hyperelastic, viscoelastic, and charged solids. Emphasis on solution methods required to determine the stress, strain, and flow fields in boundary value problems of simplified geometries, including problems for contact of two bodies. A knowledge of tensor fields, indicial notation, and partial differential equations is required. Prerequisite: Mathematics 114 or equivalent, and Biomedical Engineering 229 or consent of instructor. Instructor: Setton. 3 units.

842(320). Medical Ultrasound Transducers. A study of the design, fabrication, and evaluation of medical ultrasound transducers. Topics include wave propagation in piezoelectric crystals, Mason and KLM circuit models, linear arrays and two-dimensional arrays, piezoelectric ceramic/epoxy composite materials, piezoelectric polymers, and photo-acoustic materials. Consent of instructor required. Instructor: S. Smith. 3 units.

844(321). Advanced Ultrasonic Imaging. This course provides students with a mathematical basis of ultrasonic imaging methods. Topics include K-space, descriptions of ultrasonic imaging, ultrasonic beam-former design, tissue motion and blood flow imaging methods, and novel ultrasonic imaging methods. Students conduct extensive simulations of ultrasonic imaging methods. Prerequisite: BME 303(233). Instructor: Trahey. 3 units.

846(333). Biomedical Imaging. A study of the fundamentals of information detection, processing, and presentation associated with imaging in biology and medicine. Analysis of coherent and incoherent radiation and various image generation techniques. Design and analysis of modern array imaging systems as well as systems. Instructor: von Ramm. 3 units.

848L(334L). Radiology in Practice. Designed to complement BME 233 Modern Diagnostic Imaging Systems. Review and real-life exercises on principles of modern medical imaging systems with emphasis on the engineering aspects of image acquisition, reconstruction and visualization, observations of imaging procedures in near clinical settings, and hands-on experience with the instruments. Modalities covered include ultrasound, CT, MRI, nuclear medicine and optical imaging. Prerequisite: BME 303(233) or equivalent. Instructor: Trahey. 3 units. C-L: Medical Physics 738(338)

850(335). Advances in Photonics: An Overview of State-of-the-Art Techniques and Applications. The main goal of this course is to provide and overview of various photonics techniques and their applications. The purpose is to enhance the students' breath of understanding and knowledge of advanced techniques and introduce them to the wide variety of applications in photonics, the science and technology associated with interactions of light with matter. Examples of topics include: High-resolution Luminescence Techniques, Raman Techniques, Optical Coherence Techniques, Ultrafast Laser-base Techniques, Near-Filed and Confocal Optical Techniques, Remote Sensing Techniques, Advanced Light Measurement Techniques, Optical Biosensors, Nano Micro Electrooptics Systems, Highthroughput Assays using Optical Detection, Photonics Meta Materials and Applications, Optics in Telecommunications, and Nanophotonics. The lectures will be presented by faculty members who are leaders in their areas of research in photonics. Instructor: Vo-Dinh. 3 units. C-L: Chemistry 630(335).

899(399). Special Readings in Biomedical Engineering. Individual readings in advanced study and research areas of biomedical engineering. Approval of director of graduate studies required. 1 to 3 units each. Instructor: Staff. Variable credit.