Brenton D. Hoffman

Image of Brenton D. Hoffman

Assistant Professor of Biomedical Engineering

Appointments and Affiliations
  • Assistant Professor of Biomedical Engineering
  • Assistant Professor of Biomedical Engineering
  • Assistant Professor in Cell Biology
Contact Information:
Education:

  • Ph.D. University of Pennsylvania, 2007

Research Interests:

Dr. Hoffman’s research focuses on understanding, on a molecular level, how mechanical and chemical cues from the environment are detected, integrated, and manipulated by cells to dictate physiological and patho-physiological responses important in vascular biology.

Specialties:

Biological Materials
Polymer and Protein Engineering
Cardiovascular
Tissue Repair, Tissue Engineering

Awards, Honors, and Distinctions:

  • Post-doctoral Fellow, American Heart Association, 2009-2011
  • Cardiovascular Research Training Grant (T32), National Institutes of Health, 2007-2009
  • Ashton Fellowship in Engineering, 2002-2007

Courses Taught:
  • BME 302L: Fundamentals of Biomaterials and Biomechanics (AC or GE)
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 527: Cell Mechanics and Mechanotransduction
  • BME 527: Cell Mechanics and Mechanotransduction (GE, BB, MC)
  • BME 899: Special Readings in Biomedical Engineering

Representative Publications: (More Publications)
    • Ellis, K; Hoffman, BD; Bagnat, M, The vacuole within: how cellular organization dictates notochord function., BioArchitecture, vol 3 no. 3 (2013), pp. 64-68 [10.4161/bioa.25503] [abs].
    • Goguen, BN; Hoffman, BD; Sellers, JR; Schwartz, MA; Imperiali, B, Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes, Angewandte Chemie-International Edition, vol 50 no. 25 (2011), pp. 5666-5669 [abs].
    • Hoffman, BD; Grashoff, C; Schwartz, MA, Dynamic molecular processes mediate cellular mechanotransduction, Nature, vol 475 no. 7356 (2011), pp. 316-323 [10.1038/nature10316] [abs].
    • Goguen, BN; Hoffman, BD; Sellers, JR; Schwartz, MA; Imperiali, B, Light-triggered myosin activation for probing dynamic cellular processes, Angewandte Chemie International Edition, vol 50 no. 25 (2011), pp. 5667-5670 [10.1002/anie.201100674] [abs].
    • Eucker, SA; Hoffman, BD; Natesh, R; Ralston, J; Armstead, WM; Margulies, SS, Development of a fluorescent microsphere technique for rapid histological determination of cerebral blood flow, Brain Research, vol 1326 (2010), pp. 128-134 [abs].